Urinary 5-hydroxyindoleacetic acid in 8-hour collections as an aid in diagnosis of coeliac disease.
نویسندگان
چکیده
8-hour urine excretions of 5-hydroxyindoleacetic acid (5-HIAA) were measured in 18 children with coeliac disease before treatment and the results expressed as microgram 5-HIAA/mg creatinine. Similar measurements were made on urine collections from an age-matched control group of 24 children. Significantly higher values of 5-HIAA excretion were found in children with untreated coeliac disease. Measurement of the 5-HIAA: creatinine ratio in 8-hour urine collections is therefore proposed as an aid in the diagnosis of coeliac disease.
منابع مشابه
Urine of Children with Untreated Coeliac Disease
Chaliacombe, D. N., Brown, G. A., Black, S. C., and Storrie, M. H. (1972). Archives of Disease in Childhood, 47, 442. Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease. 24-hour urine excretions of 5-hydroxyindoleacetic acid (5HIAA) have been measured in 13 children with coeliac disease before treatment. All were excreting more 5HIAA than an ag...
متن کاملIncreased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease.
Chaliacombe, D. N., Brown, G. A., Black, S. C., and Storrie, M. H. (1972). Archives of Disease in Childhood, 47, 442. Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease. 24-hour urine excretions of 5-hydroxyindoleacetic acid (5HIAA) have been measured in 13 children with coeliac disease before treatment. All were excreting more 5HIAA than an ag...
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The usefulness of the xylose tolerance test as a screening procedure for coeliac disease has been reassessed in 54 children with suspected coeliac disease. 5- and 24-hour urinary excretion rates of xylose were of no value in discriminating between patients with and without coeliac disease; similarly, the 3-hour blood xylose concentration was nondiscriminatory. Three (15-8%) patients with subtot...
متن کاملThe clinical and laboratory correlates of an increased urinary 5-hydroxyindoleacetic acid.
Over a five-and-a-half-year period, there were 298 laboratory requests for urinary 5-hydroxyindoleacetic acid (5-HIAA). The clinical and laboratory associations of the 24 patients in which there were 43 urinary 5-HIAA 24-h collection results greater than the laboratory upper reference limit are detailed. Four were confirmed carcinoid tumours and two were phaeochromocytomas. Flushing was a promi...
متن کاملComparison of 24-h and overnight samples of urinary 5-hydroxyindoleacetic acid in patients with intestinal neuroendocrine tumors
Neuroendocrine tumors (NETs) arising in the small intestine are known to produce vasoactive substances, including serotonin, that may result in the carcinoid syndrome (flushing, diarrhea, bronchoconstriction, and carcinoid heart disease). Measurement of the serotonin breakdown product 5-hydroxyindoleacetic acid (5-HIAA) in urine is important in diagnosing and monitoring of patients with intesti...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 50 10 شماره
صفحات -
تاریخ انتشار 1975